Based on independent third-party laboratory analysis
Category pass rate: 76% pass rate — 24% of products fail. Additionally, 47% of Bangladesh-sourced turmeric contains intentionally-added lead.
Contamination risk: HIGH. 47% of Bangladesh turmeric has intentionally-added lead (lead chromate) to enhance yellow color. Always check country of origin.
Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.
Safety
Warfarin and other anticoagulants
Curcumin has antiplatelet activity in laboratory studies. No study examines it with any anticoagulant or antiplatelet drug; an additive effect is theoretical.
Curcumin and its derivatives prolong activated partial thromboplastin time (aPTT) and prothrombin time (PT) by inhibiting the generation of thrombin and activated factor X (FXa). This antiplatelet and anticoagulant activity potentiates the effects of blood-thinning medications.
This row describes concentrated turmeric or curcumin supplements rather than a specific dose, not turmeric used in cooking.
Theoretical mild additive antiplatelet effect. Limited published case reports.
Curcumin has weak antiplatelet effects and may inhibit CYP2C9 in vitro. Clinical impact at standard supplement doses uncertain.
Aspirin and NSAIDs
Curcumin has antiplatelet activity in laboratory studies. No study examines it with any anticoagulant or antiplatelet drug; an additive effect is theoretical.
Curcumin and its derivatives prolong activated partial thromboplastin time (aPTT) and prothrombin time (PT) by inhibiting the generation of thrombin and activated factor X (FXa). This antiplatelet and anticoagulant activity potentiates the effects of blood-thinning medications.
This row describes concentrated turmeric or curcumin supplements rather than a specific dose, not turmeric used in cooking.
Theoretical additive antiplatelet effect with aspirin. Monitor for bruising or unusual bleeding.
Turmeric and curcumin high-dose has antiplatelet activity that is additive to aspirin's COX-1 inhibition.
Diabetes medications (metformin, sulfonylureas)
No interaction concern with metformin. No benefit is claimed.
Curcumin has weak CYP and P-gp modulation effects in vitro. Metformin is not significantly metabolized by CYP enzymes; clinical interaction unlikely.
CYP3A4 substrates
This row describes concentrated turmeric or curcumin supplements rather than a specific dose, not turmeric used in cooking.
Generally minor. Monitor BP with high-dose supplementation.
High-dose curcumin has anti-inflammatory and mild antihypertensive activity. Weak CYP modulation in vitro.
Theoretical mild interaction. Clinically minor.
High-dose curcumin has weak CYP modulation in vitro. Bisoprolol interaction theoretical.
Tacrolimus or cyclosporine
Basis: Theoretical
Stop 2 weeks before surgery
High-dose antiplatelet effect.
Educational information only. This is not medical advice. These statements have not been evaluated by the FDA. Talk to your prescriber before starting, stopping, or combining any supplement with prescription medication.