Ginger's active compounds (gingerols and shogaols) work through multiple pathways: (1) antagonize 5-HT3 serotonin receptors, the same target as ondansetron (Zofran), explaining anti-nausea effects; (2) inhibit COX-2 and 5-LOX inflammatory enzymes, similar mechanism to NSAIDs but without GI damage; (3) inhibit prostaglandin synthesis, reducing pain and menstrual cramps; (4) stimulate gastric motility and bile secretion, improving digestion; (5) inhibit thromboxane synthase, reducing platelet aggregation (the anticoagulant concern).
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Not medical advice. Based on published clinical research and systematic reviews.