NMN · Resveratrol · Vitamin D + K2. The foundational stack
Skip K2 if you're on warfarin (Coumadin), because it interferes with anticoagulant effect. Resveratrol can mildly thin blood; pause 1 week before surgery.
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Rate your overall energy + recovery (1-10). Any aches, sleep changes, or mood shifts?
Daily check-ins build your personal data set. After 7 days, you'll start seeing trends and correlations.
NMN (nicotinamide mononucleotide) is a precursor to NAD+. The human trials cited for it measured something narrower than the usual claim: NMN improved muscle insulin sensitivity in prediabetic women (Yoshino et al., 2021, PMID 33888596) and raised plasma NMN and insulin in healthy subjects (Yamane et al., 2023, PMID 37344088). Neither showed NAD+ restored to youthful levels. Resveratrol activates sirtuins and extended lifespan in yeast (Howitz et al., 2003, PMID 12939617); that result is not a human longevity finding. Three years of low-dose MK-7 slowed the age-related decline in bone mineral density in 244 healthy postmenopausal women (Knapen et al., 2013, PMID 23525894). That trial measured bone, not arteries.
NMN + resveratrol effects are subtle but measurable in week 1. Most users report a 1-2 point bump in afternoon energy. Vitamin D needs 4-6 weeks to raise serum levels meaningfully.
NAD+ levels are climbing toward youthful baseline. If you're tracking biomarkers, schedule a serum test at day 30 to confirm.
Review your daily energy and recovery scores. All three compounds are safe for ongoing daily use. Consider a serum 25(OH)D test to dial in your D3 dose; aim for 50-80 ng/mL.
These protocols are based on published peer-reviewed research and are not medical advice. Consult your healthcare provider before starting any supplement regimen, especially if you take prescription medications.